Polynucleotides are powerful injectable bio-stimulators, highlighting their capacity for tissue regeneration and improvement of dermal health.
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The mechanism of action of polynucleotides for dark circles and their use on the skin differs from traditional dermal fillers. Instead of providing an immediate mechanical volume, they act as biological stimulators that activate the body’s own regenerative capacity.
These compounds are highly purified DNA fractions that, when infiltrated into the dermis, trigger a cascade of physiological processes at the cellular level.
- Fibroblast Activation (Via A2A Receptors)
- Collagen Synthesis and Matrix
- RemodelingDeep Hydration (“Scaffolding” Effect)
- Anti-inflammatory Action and Angiogenesis
- Antioxidant Protection
While a traditional dermal filler (hyaluronic acid) requires a mechanical and volumetric solution, polynucleotides act on fibroblasts to repair the structure.
What scientific evidence supports its effectiveness in cell regeneration and tissue repair?
Current scientific evidence supports the effectiveness of polynucleotides (PN) and polydeoxyribonucleotides (PDRN) as bioregenerative agents and not merely as aesthetic fillers. Various clinical studies and systematic reviews validate its ability to repair tissues at the cellular level through specific biological mechanisms.
Science supports that polynucleotides do not function as an internal “makeup” that hides the defect, but as a biological fertilizer. Polynucleotides cause the skin to regenerate with a denser and more resistant structure.
Polynucleotides for dark circles
The biological source of injectable polynucleotides used in aesthetic medicine is DNA extracted from the gonads of fish, specifically from the germ cells (sperm) of the salmonid family,
These specific biological sources are selected due to their high biocompatibility with the human organism and their ability to induce tissue regeneration with a minimal risk of immunological reaction after processing.
What is the mechanism by which polynucleotides can improve the appearance of dark circles?
Polynucleotides (PN) improve the appearance of dark circles by directly targeting the structural and vascular quality of the skin in the periocular region, rather than simply filling a gap as traditional fillers do. Their mechanism for combating darkness and a tired appearance is based on three fundamental biological pillars: thickening of the dermis (the “masking” effect), improvement of microcirculation, and reduction of inflammation.
Dermal Thickening (Masking Effect)
The primary cause of many dark circles is that the skin of the lower eyelid is exceptionally thin, allowing the blood vessels and underlying orbicularis oculi muscle to show through, creating a dark or bluish tone.
- Biostimulation: Polynucleotides activate fibroblasts to synthesize new collagen and elastin.
- Visible result: This produces a measurable increase in the thickness and density of the dermis. By thickening the skin, its transparency is reduced, “masking” or concealing the dark vascular network beneath, thus visually brightening the area.
Angiogenesis and vascular enhancement (Color Correction)
Unlike other injectables, polynucleotides have the ability to modulate the vascular environment, targeting the origin of the purplish or brownish color:
- VEGF Stimulation: They increase the expression of Vascular Endothelial Growth Factor (VEGF), which promotes the formation of new blood vessels (angiogenesis) and improves microcirculation.Pigment Elimination: By improving blood flow, venous stasis is reduced, facilitating the elimination of hemosiderin and melanin, which are responsible for the dark pigmentation of under-eye circles.
Anti-inflammatory action (Pigmented/Red Dark Circles)
Many dark circles have a chronic inflammatory component that exacerbates pigmentation.
- Immune modulation: Polynucleotides reduce inflammatory markers (cytokines) and block the activity of free radicals.
- Soothing effect: This calms the tissue, reducing erythema (redness) and preventing post-inflammatory hyperpigmentation that darkens the eye contour.
Restructuring without the “Tyndall Effect” (Safe Hydration)
One of the biggest risks of treating dark circles with hyaluronic acid is chronic edema (swelling) or the Tyndall effect (bluish reflection), since hyaluronic acid attracts a lot of water.
- Non-volumetric hydration: Polynucleotides deeply hydrate by creating a three-dimensional matrix that retains water, improving firmness and eliminating the “parchment-like” or crepey appearance (fine lines).
- Safety: They achieve this without adding excessive mechanical volume or attracting water uncontrollably, thus preventing swelling and maintaining a natural appearance..
Polynucleotides promote the production of collagen and elastin, offering benefits such as increased elasticity, reduction of fine wrinkles and anti-inflammatory effects, especially in the periocular area and on delicate skin.
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